Protein Structures
STRUCTURALPredicted 3D structures for all SMA research targets using AlphaFold2, AlphaFold-3, ESMfold, and Boltz-2. Each structure is scored by pLDDT (predicted Local Distance Difference Test) — a per-residue confidence metric that tells you how reliable each part of the structure is for drug design.
pLDDT Confidence InterpretationWhy this matters for SMA drug design:3D protein structure directly determines which pockets small molecules can bind. Use the “3D” button to visualize structures interactively.
pLDDT ≥ 90: Very high confidence
Suitable for docking and structure-based drug design.
pLDDT 70–90: Confident
Backbone reliable. Usable for initial virtual screening.
pLDDT 50–70: Low confidence
Unreliable — often flexible loops or poorly conserved regions.
pLDDT < 50: Very low
Likely disordered. Do NOT use for docking.
Monomer structures via AlphaFold DB v6 (EMBL-EBI), ESMfold v1, and Boltz-2. Multi-chain complexes via AlphaFold-3 (alphafoldserver.com) — see AF3 viewer above. Method badges indicate prediction source. MW estimates: ~110 Da per residue.
Interactive · AlphaFold-3 Complexes
Protein–Protein Complex Predictions
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Open 3D viewer →
Multi-chain complexes (PPI / NMJ stoichiometry / regen-axis interactions), rendered in an interactive 3D viewer with per-residue pLDDT colouring and PAE maps. The list is live — new folds appear automatically. The per-target index below shows one best monomer per gene.
Interactive · OpenFold-3 Folds
PPI & Binder Predictions
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OpenFold-3 view →
OpenFold-3 co-folding predictions: PPI/holo complexes and de-novo binder designs scored by iPTM. Filter by type, search by target symbol, and view the full ranked list. The list is live — new folds appear automatically.
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