SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
TARGETproteinHomo sapiens

TGFBR1TGF-beta Receptor Type-1

Linked hypotheses (20)

  • Off-target candidate: **4AP_ampyra** → TGFBR1 (iPTM=0.982)
    mechanismconf 98%
  • Off-target candidate: **ataluren** → TGFBR1 (iPTM=0.976)
    mechanismconf 98%
  • Off-target candidate: **ataluren** → TGFBR1 (iPTM=0.979)
    mechanismconf 98%
  • Off-target candidate: **4AP_ampyra** → TGFBR1 (iPTM=0.980)
    mechanismconf 98%
  • Off-target candidate: **4AP_ampyra** → TGFBR1 (iPTM=0.983)
    mechanismconf 98%
  • Off-target candidate: **4AP_ampyra** → TGFBR1 (iPTM=0.979)
    mechanismconf 98%
  • Off-target candidate: **pyridostigmine** → TGFBR1 (iPTM=0.974)
    mechanismconf 97%
  • Off-target candidate: **pyridostigmine** → TGFBR1 (iPTM=0.969)
    mechanismconf 97%
  • Off-target candidate: **pyridostigmine** → TGFBR1 (iPTM=0.973)
    mechanismconf 97%
  • Off-target candidate: **pyridostigmine** → TGFBR1 (iPTM=0.969)
    mechanismconf 97%
  • Off-target candidate: **ataluren** → TGFBR1 (iPTM=0.972)
    mechanismconf 97%
  • ataluren off-target binding to TGFBR1
    repurposingconf 96%
  • Off-target candidate: **ataluren** → TGFBR1 (iPTM=0.962)
    mechanismconf 96%
  • Off-target candidate: **ataluren** → TGFBR1 (iPTM=0.948)
    mechanismconf 95%
  • Off-target candidate: **riluzole** → TGFBR1 (iPTM=0.948)
    mechanismconf 95%
  • riluzole off-target binding to TGFBR1
    repurposingconf 95%
  • ataluren off-target binding to TGFBR1
    repurposingconf 95%
  • Off-target candidate: **fasudil** → TGFBR1 (iPTM=0.939)
    mechanismconf 94%
  • Off-target candidate: **fasudil** → TGFBR1 (iPTM=0.935)
    mechanismconf 94%
  • Off-target candidate: **fasudil** → TGFBR1 (iPTM=0.930)
    mechanismconf 93%

Top compound hits (0)

No ranked compounds yet for TGFBR1.

Linked claims (50)

TypePredicateConfSource
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm98%
drug targetboltz2_offtarget_iptm97%
drug targetboltz2_offtarget_iptm97%
drug targetboltz2_offtarget_iptm97%
drug targetboltz2_offtarget_iptm97%
drug targetboltz2_offtarget_iptm97%
drug targetboltz2_offtarget_iptm97%

Showing 20 of 50.

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