SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
TARGETproteinHomo sapiens

SCN5A

Linked hypotheses (20)

  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.915)
    targetconf 91%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.892)
    targetconf 89%
  • PAK4_chembl_1 binds SCN5A_pore (Boltz-2 iPTM=0.868)
    targetconf 87%
  • PAK4_chembl_1 × SCN5A_pore affinity via computational screening (Boltz-2)
    mechanismconf 87%
  • PAK4_chembl_1 binds SCN5A_pore (Boltz-2 iPTM=0.867)
    targetconf 87%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.868)
    targetconf 87%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.857)
    targetconf 86%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.857)
    targetconf 86%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.846)
    targetconf 85%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.849)
    targetconf 85%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.852)
    targetconf 85%
  • BDNF_mimic × SCN5A_pore affinity via computational screening (Boltz-2)
    mechanismconf 85%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.837)
    targetconf 84%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.841)
    targetconf 84%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.840)
    targetconf 84%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.827)
    targetconf 83%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.830)
    targetconf 83%
  • PAK4_chembl_1 binds SCN5A_pore (Boltz-2 iPTM=0.832)
    targetconf 83%
  • riluzole binds SCN5A_pore (Boltz-2 iPTM=0.824)
    targetconf 82%
  • BDNF_mimic binds SCN5A_pore (Boltz-2 iPTM=0.820)
    targetconf 82%

Top compound hits (0)

No ranked compounds yet for SCN5A.

Linked claims (20)

TypePredicateConfSource
drug targetboltz2_offtarget_iptm70%
drug targetboltz2_offtarget_iptm70%
drug targetboltz2_offtarget_iptm60%
drug targetboltz2_offtarget_iptm60%
drug targetboltz2_offtarget_iptm60%
drug targetboltz2_offtarget_iptm60%
drug targetboltz2_offtarget_iptm53%
drug targetboltz2_offtarget_iptm53%
drug targetboltz2_offtarget_iptm53%
drug targetboltz2_offtarget_iptm53%
drug targetboltz2_offtarget_iptm52%
drug targetboltz2_offtarget_iptm51%
drug targetboltz2_offtarget_iptm48%
drug targetboltz2_offtarget_iptm46%
drug targetboltz2_offtarget_iptm46%
drug targetboltz2_offtarget_iptm46%
drug targetboltz2_offtarget_iptm43%
drug targetboltz2_offtarget_iptm42%
drug targetboltz2_offtarget_iptm41%
drug targetboltz2_offtarget_iptm40%
Login → Command Center