TARGETproteinHomo sapiens
PAK4 — p21-Activated Kinase 4
Description
Alternative LIMK2 activator, group II PAK. Direct phosphorylation of LIMK2 leading to CFL2 inactivation.
Linked hypotheses (20)
- Off-target candidate: **4AP_ampyra** → PAK4 (iPTM=0.959)mechanismconf 96%
- Off-target candidate: **4AP_ampyra** → PAK4 (iPTM=0.957)mechanismconf 96%
- Off-target candidate: **4AP_ampyra** → PAK4 (iPTM=0.952)mechanismconf 95%
- Off-target candidate: **riluzole** → PAK4 (iPTM=0.936)mechanismconf 94%
- PAK4_chembl_1 binds LIMK2_aC (Boltz-2 iPTM=0.944)targetconf 94%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- Off-target candidate: **4AP_ampyra** → PAK4 (iPTM=0.911)mechanismconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
- [Protein Interaction] PAK4 is implicated in SMA pathogenesis based on 18 converging claimstargetconf 91%
Top compound hits (0)
No ranked compounds yet for PAK4.
Linked claims (50)
| Type | Predicate | Conf | Source |
|---|---|---|---|
| drug target | boltz2_offtarget_iptm | 96% | — |
| drug target | boltz2_offtarget_iptm | 96% | — |
| drug target | boltz2_offtarget_iptm | 96% | — |
| drug target | boltz2_offtarget_iptm | 96% | — |
| drug target | boltz2_offtarget_iptm | 95% | — |
| drug target | boltz2_offtarget_iptm | 95% | — |
| drug target | boltz2_offtarget_iptm | 94% | — |
| drug target | boltz2_offtarget_iptm | 94% | — |
| drug target | boltz2_offtarget_iptm | 91% | — |
| drug target | boltz2_offtarget_iptm | 91% | — |
| drug target | boltz2_offtarget_iptm | 91% | — |
| drug target | boltz2_offtarget_iptm | 91% | — |
| drug target | boltz2_offtarget_iptm | 90% | — |
| drug target | boltz2_offtarget_iptm | 90% | — |
| drug target | boltz2_offtarget_iptm | 87% | — |
| drug target | boltz2_offtarget_iptm | 87% | — |
| drug target | boltz2_offtarget_iptm | 86% | — |
| drug target | boltz2_offtarget_iptm | 86% | — |
| drug target | boltz2_offtarget_iptm | 85% | — |
| drug target | boltz2_offtarget_iptm | 85% | — |
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