SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
TARGETproteinHomo sapiens

CHRNG

Linked hypotheses (20)

  • LIMKi3 × CHRNG_fetal affinity via computational screening (Boltz-2)
    mechanismconf 88%
  • LIMKi3 binds CHRNG_fetal (Boltz-2 iPTM=0.884)
    targetconf 88%
  • MuSK_chembl_1 binds CHRNG_fetal (Boltz-2 iPTM=0.816)
    targetconf 82%
  • MuSK_chembl_1 × CHRNG_fetal affinity via computational screening (Boltz-2)
    mechanismconf 80%
  • MuSK_chembl_1 binds CHRNG_fetal (Boltz-2 iPTM=0.803)
    targetconf 80%
  • Off-target candidate: **ataluren** → CHRNG (iPTM=0.766)
    mechanismconf 77%
  • ataluren off-target binding to CHRNG
    repurposingconf 77%
  • LIMKi3 × CHRNG_fetal affinity via computational screening (Boltz-2)
    mechanismconf 77%
  • LIMKi3 binds CHRNG_fetal (Boltz-2 iPTM=0.774)
    targetconf 77%
  • riluzole × CHRNG_fetal affinity via computational screening (Boltz-2)
    repurposingconf 76%
  • riluzole binds CHRNG_fetal (Boltz-2 iPTM=0.761)
    targetconf 76%
  • curcumin × CHRNG_fetal affinity via computational screening (Boltz-2)
    mechanismconf 73%
  • curcumin binds CHRNG_fetal (Boltz-2 iPTM=0.735)
    targetconf 73%
  • haloperidol × CHRNG_fetal affinity via computational screening (Boltz-2)
    repurposingconf 73%
  • haloperidol binds CHRNG_fetal (Boltz-2 iPTM=0.735)
    targetconf 73%
  • PAK4_chembl_1 × CHRNG_fetal affinity via computational screening (Boltz-2)
    mechanismconf 73%
  • PAK4_chembl_1 binds CHRNG_fetal (Boltz-2 iPTM=0.733)
    targetconf 73%
  • ataluren off-target binding to CHRNG
    repurposingconf 71%
  • Off-target candidate: **ataluren** → CHRNG (iPTM=0.711)
    mechanismconf 71%
  • Off-target candidate: **riluzole** → CHRNG (iPTM=0.702)
    mechanismconf 70%

Top compound hits (0)

No ranked compounds yet for CHRNG.

Linked claims (30)

TypePredicateConfSource
drug targetboltz2_offtarget_iptm77%
drug targetboltz2_offtarget_iptm77%
drug targetboltz2_offtarget_iptm71%
drug targetboltz2_offtarget_iptm71%
drug targetboltz2_offtarget_iptm70%
drug targetboltz2_offtarget_iptm70%
drug targetboltz2_offtarget_iptm67%
drug targetboltz2_offtarget_iptm66%
drug targetboltz2_offtarget_iptm66%
drug targetboltz2_offtarget_iptm66%
drug targetboltz2_offtarget_iptm66%
drug targetboltz2_offtarget_iptm66%
drug targetboltz2_offtarget_iptm65%
drug targetboltz2_offtarget_iptm65%
drug targetboltz2_offtarget_iptm62%
drug targetboltz2_offtarget_iptm62%
drug targetboltz2_offtarget_iptm62%
drug targetboltz2_offtarget_iptm62%
drug targetboltz2_offtarget_iptm61%
drug targetboltz2_offtarget_iptm61%

Showing 20 of 30.

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