SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
TARGETproteinHomo sapiens

CFL2

Linked hypotheses (20)

  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%
  • [Survival] CFL2 is implicated in SMA pathogenesis based on 9 converging claims
    targetconf 97%

Top compound hits (10)

Compound IDSMILESScoreTier
O=C1CC(Cc2ccc(F)cc2)O=C1CC(Cc2ccc(F)cc2)Oc2ccc(O)cc211.522early
O=C(O)CCc1cc(Cl)cc(BO=C(O)CCc1cc(Cl)cc(Br)c11.516early
O=C1CC(CSc2ccc(F)cc2O=C1CC(CSc2ccc(F)cc2)Oc2ccc(O)cc211.465early
O=C1CCN(C(=O)Nc2ccc(O=C1CCN(C(=O)Nc2ccc(Oc3ccncc3)cc2)CC10.945early
O=C1CCN(Cc2ccc(Oc3ccO=C1CCN(Cc2ccc(Oc3ccncc3)cc2)CCN10.940early
CCn1nc(C(F)(F)F)cc1-CCn1nc(C(F)(F)F)cc1-c1cc(C)cc(S(N)(=O)=O)c10.937early
COc1cc(N[C@@H]2CCC(=COc1cc(N[C@@H]2CCC(=O)C2)cc(-c2ccncc2)c10.935early
C[C@@H]1CC(=O)CN1Cc1C[C@@H]1CC(=O)CN1Cc1ccccc1NC(=O)C(F)(F)F0.932early
O=C1CCN(Cc2ccccc2NC(O=C1CCN(Cc2ccccc2NC(=O)C(F)(F)F)CC10.932early
CC(C)(C)C(=O)Nc1ccccCC(C)(C)C(=O)Nc1ccccc1CN1CC2(CCOCC2)C10.930early

Linked claims (50)

TypePredicateConfSource
drug targetboltz2_iptm90%
drug targetboltz2_iptm87%
drug targetboltz2_iptm86%
drug targetboltz2_iptm84%
protein interactionaf3_iptm83%
protein interactionaf3_iptm83%
drug targetboltz2_iptm82%
protein interactionaf3_iptm80%
drug targetboltz2_iptm78%
drug targetboltz2_iptm78%
drug targetboltz2_iptm77%
drug targetboltz2_iptm75%
drug targetboltz2_iptm73%
drug targetboltz2_iptm73%
drug targetboltz2_iptm66%
drug targetboltz2_iptm63%
drug targetboltz2_iptm59%
drug targetboltz2_iptm55%
drug targetboltz2_iptm52%
drug targetboltz2_iptm50%

Showing 20 of 50.

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