Synergy Predictions
HYPOTHESISAI-predicted drug-target synergy scores combining docking affinity, literature evidence, pathway overlap, and claim support. Identifies the most promising multi-mechanism therapeutic combinations for SMA.
▶How does Synergy Scoring work?
Each drug-target pair is scored across four independent evidence layers: docking (DiffDock binding affinity), literature (quality-filtered claim co-mentions), pathway (shared KEGG/STRING network proximity), and claims (weighted by confidence and source independence).
Combinations where all four layers agree rank highest. Single-layer signals are deprioritized.
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