SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
Targets
Trials
Drugs
Datasets
Sources
Claims
Evidence
Hypotheses

Target Prioritization

COMPUTATIONAL

Multi-criteria scoring across 7 dimensions: evidence strength, biological coherence, fragility relevance, interventionability, translational feasibility, novelty, and contradiction risk. Composite score determines Phase 3 priority.

How does Target Scoring work?

Each target receives a composite score from 8 independent dimensions, normalized 0–1 and combined via weighted average. Weights are transparent and reproducible (see the convergence engine).

Top 5 composite scores are Tier A (primary candidates), ranks 6–15 are Tier B (established modifiers), the remainder are Tier C (discovery).

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