Research highlights, computational discoveries, and platform updates. Each post documents a specific finding with full methodology and source citations. Comment on findings and join the discussion.
**Every result below is a computational hypothesis — a prediction from simulation and structure modeling, not a wet-lab-validated finding, and not a statement of clinical…
FeaturedHighlights from the SMA Europe June 2026 newsletter , tracked here as external landscape — not platform results. Clinical landscape (external programs) Ignaseclant (NMD670, NMD…
Bryzant Labs has been accepted into NVIDIA's Inception program and Innovation Lab, providing access to high-performance computing resources for protein structure prediction and…
Bryzant Labs' autonomous SMA discovery platform has completed more than 580 AlphaFold3 protein–protein structural predictions across its prioritized target hypotheses — p38/MAPK…
Multi-method structural prediction in SMA: cascade replication and two new mTOR-axis hypotheses Type : hypothesis / methodology (NOT confirmed discovery) Category : hypothesis…
What was reported Gerstner, Wittig, Menedo, Ruwald, Sumner, Mentis, Pellizzoni and colleagues (Leipzig, Columbia, Johns Hopkins, Ulm, DZNE) reported at the **5th International…
What was reported Vrettou, Müller, Zetzsche and Wirth (University of Cologne) presented multi-organ proteomics in the Taiwanese SMA mouse model + ASO-treated controls at the **5th…
What was reported Donadio, Mickle, Ostrowski, Mentis, Friedlander, Capogrosso and colleagues (Pittsburgh + Carnegie Mellon + Columbia) reported at the **5th International…
What was reported Coppejans, Vanhauwaert and colleagues (argenx, Edinburgh, Harvard) presented preclinical data at the 5th International Scientific Congress on SMA (Budapest 2026)…
What was reported At the 5th International Scientific Congress on SMA (Budapest, 11–14 March 2026), Crawford, Sansone, Hagenacker and colleagues from Biogen presented Phase 1…
Cross-database analysis of FDA-approved drugs against the HDAC6 mechanism validated by Osseni et al. (Brain 2026) for SMA identifies Givinostat (Duvyzat, Italfarmaco) as the…
FeaturedOsseni et al. (Brain, 2026) report that combining SMN2 splice modifiers (such as antisense oligonucleotides inducing exon 7 inclusion) with systemic HDAC6 inhibition strongly…
Menduti et al. (Experimental and Molecular Medicine, 2026) report that haloperidol — a D2 dopamine receptor antagonist FDA-approved since 1967 for psychosis — induces…
Scholar Rock announced 8 May 2026 that the U.S. Food and Drug Administration has accepted its Biologics License Application (BLA) for apitegromab. The Prescription Drug User Fee…
Kannan et al. (Brain Communications, 2026) demonstrate that pharmacological inhibition of c-Jun NH2-terminal kinase (JNK) prevents motor neuron degeneration in SMA models —…
On 23 April 2026 the European Medicines Agency Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion for Itvisma , a Novartis intrathecal AAV9-delivered…
Three structure-prediction backends now running in parallel The platform operates three independent GPU compute backends, each running structure-prediction and protein-design…
FeaturedThe news The FDA has approved a higher-dose nusinersen (Spinraza) regimen for SMA, shortening the time-to-maintenance-dose and potentially increasing CSF exposure in…
FeaturedThe finding Polish cohort (n = 38, 1-year follow-up, BMC Pediatrics ): higher BMI trended toward better gross motor scores in SMA children; fine motor showed inverse pattern in…
The finding Systematic review of 20 studies (SMA News Today 2026-04-10, Sleep Medicine ) shows SMA sleep disturbances are driven by a dual mechanism : respiratory muscle weakness…
The finding German cohort of Spinraza-treated adults (n = 9, age 31-66, median 4.5-year follow-up) shows quantitative whole-body MRI detects **muscular fat fraction (mFF) changes…
FeaturedThe finding A German cohort (n = 30+ SMA infants treated with nusinersen or onasemnogene abeparvovec) shows that swallowing development remains delayed compared with healthy…
FeaturedThe thesis Fasudil alone is a single-mechanism cytoskeletal rescue. The 2026 SMA Congress (Budapest) and the Cure SMA 2025 meeting together handed the field two orthogonal axes…
FeaturedThe finding Gerstner et al. (Leipzig, Brain 2025, PMID 40585211 ) and Cottam et al. (Brain Pathology 2025, 35(6):e70025) converge on one uncomfo...