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SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
API Docs·GitHub
Christian Fischer / Bryzant Labs
—Targets
—Trials
—Drugs
—Datasets
—Sources
—Claims
—Evidence
—Hypotheses

AI-Designed VHH Nanobodies

AI-GENERATED

Therapeutic-format single-domain antibodies (VHH) designed via the mBER framework using AlphaFold2-Multimer backpropagation to optimize binder sequences against SMA-relevant targets (MuSK, KEAP1). Every row below is a de-novo designed sequence with computed interface predicted TM-score (ipTM) and per-residue pLDDT confidence. Click any row to open the full sequence with a copy button + AlphaFold2-Multimer complex PDB link.

Source PDBs:sma-research/binders/— full AlphaFold2-Multimer complexes + relaxed binder structures, per-target folders
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