SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
DRUGinvestigationalsmall molecule

triheptanoin

Brand names: Dojolvi

Mechanism

Anaplerotic substrate for energy metabolism. Positive in SMND7 mice (2021) — both survival and motor.. NOTE: Approved 2020 as Dojolvi (Ultragenyx) for LC-FAOD (long-chain fatty acid oxidation disorders); SMA use is off-label/investigational.

Approved indications

LC-FAOD (off-label for SMA)

Related claims (0)

No claims matched “triheptanoin” in free-text search.

Off-Target Findings (0)

No Boltz-2 / Chai-1 off-target panel claims recorded for this drug.

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