DRUGapprovedsmall molecule
N-Acetylcysteine
Mechanism
Glutathione precursor / antioxidant
Related claims (9)
| Type | Predicate | Conf | Source |
|---|---|---|---|
| neuroprotection | N-acetylcysteine (NAC) rescues motor neuron degeneration in SMA long-term cultures. | 53% | 26586529 |
| drug efficacy | N-acetylcysteine (NAC) ameliorates reduction in mitochondrial membrane potential in SMA spinal motor neurons. | 53% | 26586529 |
| drug efficacy | N-acetylcysteine (NAC), an antioxidant, prevents apoptosis and motor neuron death in SMN-knockdown models. | 51% | 23208423 |
| drug efficacy | N-acetylcysteine rescues reduced vitality and altered morphology in SMA cortical neurons (demonstrated in vitro). | 50% | PMID:41402453 |
| neuroprotection | N-acetylcysteine (NAC) rescues motor neuron degeneration in SMA long-term cultures (demonstrated in vitro). | 50% | PMID:26586529 |
| drug efficacy | N-acetylcysteine (NAC) ameliorates the reduction in mitochondrial membrane potential in SMA spinal motor neurons (demonstrated in vitro). | 50% | PMID:26586529 |
| drug efficacy | N-acetylcysteine (NAC) mitigates impairment in mitochondrial transport and morphology in SMA spinal motor neurons. | 45% | 26586529 |
| drug efficacy | N-acetylcysteine rescued all the parameters of SMA cortical neurons (demonstrated in vitro) | 45% | 41402453 |
| drug efficacy | N-acetylcysteine (NAC) mitigates impairment in mitochondrial transport and morphology in SMA spinal motor neurons (demonstrated in vitro). | 42% | PMID:26586529 |
Off-Target Findings (0)
No Boltz-2 / Chai-1 off-target panel claims recorded for this drug.