SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
DRUGapprovedsmall molecule

Dimethyl Fumarate

Brand names: Tecfidera

Mechanism

NRF2 activator

Related claims (1)

TypePredicateConfSource
safetySulforaphane exhibits reduced systemic toxicity compared to dimethyl fumarate while being slightly less efficacious in methylmercury-induced ALS-like pathology.53%41649614

Off-Target Findings (0)

No Boltz-2 / Chai-1 off-target panel claims recorded for this drug.

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