SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
DRUGapprovedsmall molecule

ataluren

Approved indications

duchenne-muscular-dystrophy-nonsense

Related claims (0)

No claims matched “ataluren” in free-text search.

Off-Target Findings (250)

T1: 3T3: 212untiered: 35
TargetRoleTierBoltz-2 iPTMChai-1 iPTMVerdict
CHRNGion_channelSMAT10.766Primary SMA hit
KCNA2ion_channelSMAT10.655Primary SMA hit
SCN5Aion_channelSMAT10.402Primary SMA hit
RIPK2kinaseOFF-TARGETT30.982Selectivity flag (off-target substrate)
TGFBR1kinaseSMAT30.979Selectivity flag (off-target substrate)
ACVR2BkinaseSMAT30.972Selectivity flag (off-target substrate)
P2RY6gpcrOFF-TARGETT30.968Selectivity flag (off-target substrate)
FGRkinaseOFF-TARGETT30.965Selectivity flag (off-target substrate)
MRGPRX1gpcrOFF-TARGETT30.960Selectivity flag (off-target substrate)
DYRK2kinaseOFF-TARGETT30.959Selectivity flag (off-target substrate)
ADORA3gpcrOFF-TARGETT30.959Selectivity flag (off-target substrate)
MRGPRX4gpcrOFF-TARGETT30.958Selectivity flag (off-target substrate)
MINK1kinaseOFF-TARGETT30.954Selectivity flag (off-target substrate)
RPS6KA1kinaseOFF-TARGETT30.952Selectivity flag (off-target substrate)
CDC42BPAkinaseOFF-TARGETT30.948Selectivity flag (off-target substrate)
CITkinaseOFF-TARGETT30.945Selectivity flag (off-target substrate)
STK17BkinaseOFF-TARGETT30.943Selectivity flag (off-target substrate)
OXGR1gpcrOFF-TARGETT30.938Selectivity flag (off-target substrate)
ERBB3kinaseOFF-TARGETT30.935Selectivity flag (off-target substrate)
FFAR1gpcrOFF-TARGETT30.934Selectivity flag (off-target substrate)
CHEK1kinaseOFF-TARGETT30.934Selectivity flag (off-target substrate)
PIP4K2AkinaseOFF-TARGETT30.933Selectivity flag (off-target substrate)
GPR18gpcrOFF-TARGETT30.932Selectivity flag (off-target substrate)
OPRL1gpcrOFF-TARGETT30.932Selectivity flag (off-target substrate)
GRK1kinaseOFF-TARGETT30.930Selectivity flag (off-target substrate)
CDK17kinaseOFF-TARGETT30.928Selectivity flag (off-target substrate)
PTK6kinaseOFF-TARGETT30.928Selectivity flag (off-target substrate)
MYLK3kinaseOFF-TARGETT30.928Selectivity flag (off-target substrate)
PIK3CDkinaseOFF-TARGETT30.921Selectivity flag (off-target substrate)
STYK1kinaseOFF-TARGETT30.920Selectivity flag (off-target substrate)
ERBB2kinaseOFF-TARGETT30.919Selectivity flag (off-target substrate)
PRKXkinaseOFF-TARGETT30.918Selectivity flag (off-target substrate)
GPR135gpcrOFF-TARGETT30.918Selectivity flag (off-target substrate)
STK10kinaseOFF-TARGETT30.914Selectivity flag (off-target substrate)
TACR3gpcrOFF-TARGETT30.914Selectivity flag (off-target substrate)
CLK3kinaseOFF-TARGETT30.913Selectivity flag (off-target substrate)
SCTRgpcrOFF-TARGETT30.912Selectivity flag (off-target substrate)
FZD5gpcrOFF-TARGETT30.909Selectivity flag (off-target substrate)
VIPR1gpcrOFF-TARGETT30.906Selectivity flag (off-target substrate)
CCR9gpcrOFF-TARGETT30.905Selectivity flag (off-target substrate)
MAP3K3kinaseOFF-TARGETT30.903Selectivity flag (off-target substrate)
MAP3K13kinaseOFF-TARGETT30.900Selectivity flag (off-target substrate)
TACR1gpcrOFF-TARGETT30.888Selectivity flag (off-target substrate)
CASKkinaseOFF-TARGETT30.888Selectivity flag (off-target substrate)
RPS6KA4kinaseOFF-TARGETT30.886Selectivity flag (off-target substrate)
CDK12kinaseOFF-TARGETT30.885Selectivity flag (off-target substrate)
MRGPRDgpcrOFF-TARGETT30.884Selectivity flag (off-target substrate)
SSTR4gpcrOFF-TARGETT30.879Selectivity flag (off-target substrate)
CCKBRgpcrOFF-TARGETT30.878Selectivity flag (off-target substrate)
BMXkinaseOFF-TARGETT30.872Selectivity flag (off-target substrate)

Showing top 50 of 250 targets.

Login → Command Center