SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
14,766Targets
453Trials
84Drugs
7Datasets
6,987Sources
64,683Claims
72,052Evidence
29,649Hypotheses
DRUGphase1antibody

ARGX-119

Mechanism

Anti-MuSK agonist monoclonal antibody. Coadministration with SMN2 splice modulator (SMN-C3) improves voluntary locomotion + masseter force in SMNΔ7 mouse model (Coppejans O28 Budapest 2026). Combination strategy: SMN-restore + NMJ-target.

Related claims (0)

No claims matched “ARGX-119” in free-text search.

Off-Target Findings (0)

No Boltz-2 / Chai-1 off-target panel claims recorded for this drug.

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