Cross-Species Comparative
COMPUTATIONAL▶How does Conservation Scoring work?
Each organism offers unique advantages for SMA research: Mus musculus (SMN-delta7 and Taiwanese SMA strains), Danio rerio (motor neuron fluorescent reporters), Heterocephalus glaber (resistance to neurodegeneration), Ambystoma mexicanum (complete spinal cord regeneration).
Conservation ≥71% suggests the target’s function is preserved across species and findings from model organisms are likely translatable to humans. Click any species card to filter orthologs for that organism.
Loading ortholog data…